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Updated: Oct 9, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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Renal manifestations of paediatric systemic lupus erythematosus

Thomas Dowsett1, Louise Oni2,3

  • 1Department of Paediatric Nephrology, Royal Manchester Children's NHS Trust Hospital, Manchester.

Current Opinion in Pediatrics
|December 21, 2021
PubMed

Insights

Paediatric lupus nephritis requires improved management strategies. Current treatments show inadequate response rates, highlighting the need for novel therapies and biomarkers for better patient outcomes.

Area of Science:

  • Pediatric Nephrology
  • Rheumatology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic, multisystemic autoimmune disease.
  • Approximately 20% of SLE patients present in childhood, often with more severe disease and higher rates of lupus nephritis.
  • Paediatric lupus nephritis presents unique challenges compared to adult-onset disease.

Purpose of the Study:

  • To review the current literature on the management of lupus nephritis in children.
  • To highlight the challenges and recent advancements in treating this condition.

Main Methods:

  • Comprehensive literature search of studies focusing on paediatric lupus nephritis management.
  • Analysis of current treatment guidelines, clinical trial data, and emerging therapeutic strategies.

Main Results:

  • Standard treatment involves intensive induction followed by long-term maintenance immunosuppression.
  • Complete remission rates are suboptimal (40-60%), with frequent disease flares.
  • Progression to end-stage renal disease occurs in over 10% within a decade; CKD stages 1-4 progression is less defined.
  • Biologic agents are being investigated as adjunctive therapies.

Conclusions:

  • There is a critical need for improved therapeutic outcomes in paediatric lupus nephritis.
  • Biomarkers for monitoring disease activity and novel treatment approaches are essential.
  • Further research into pathogenesis and targeted therapies holds promise for better management.
Abstract

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