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Hepatic Lipid Metabolism Disorder and Atherosclerosis
Sen Zhang1, Fenfang Hong2, Chen Ma1
1Department of Physiology, College of Medicine, Nanchang University, Nanchang, China.
Endocrine, Metabolic & Immune Disorders Drug Targets
|December 21, 2021
Summary
Disordered liver lipid metabolism, affecting cholesterol and triglycerides, is linked to atherosclerosis. Gut microbiota, inflammation, and oxidative stress also contribute to this association, increasing atherosclerosis risk.
Area of Science:
- Cardiovascular Disease Research
- Metabolic Disorders
- Hepatology
Background:
- Lipid metabolism disorders are central to atherosclerosis development.
- The liver is a key organ in regulating lipid metabolism and serum lipoproteins.
- Hepatic lipid metabolism dysfunction is increasingly linked to atherosclerosis onset.
Purpose of the Study:
- To review the association between hepatic lipid metabolism and atherosclerosis.
- To identify specific hepatic lipid pathways involved in atherosclerosis pathogenesis.
- To explore the roles of gut microbiota, inflammation, and oxidative stress in this relationship.
Main Methods:
- Literature review of clinical and experimental studies.
- Analysis of research on hepatic cholesterol synthesis and transport.
- Examination of triglyceride, lipoprotein, and fatty acid metabolism in liver disease.
Main Results:
- Hepatic cholesterol synthesis, transport, and triglyceride, lipoprotein, and fatty acid metabolism are linked to atherosclerosis.
- Gut microbiota, inflammatory response, and oxidative stress mediate the pathological association.
- Evidence supports hepatic lipid metabolism disorders as a risk factor for atherosclerosis.
Conclusions:
- Hepatic lipid metabolism plays a critical role in atherosclerosis.
- Dysregulation in liver lipid pathways significantly contributes to cardiovascular risk.
- Targeting hepatic lipid metabolism may offer therapeutic strategies for atherosclerosis.
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