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Lymphocytic hypophysitis in a man.

A T Guay, V Agnello, B C Tronic

    The Journal of Clinical Endocrinology and Metabolism
    |March 1, 1987
    PubMed
    Summary
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    This study reports the first known case of lymphocytic adenohypophysitis in a male patient. This rare condition, typically seen in women, presented with anterior hypopituitarism and an intrasellar mass.

    Area of Science:

    • Endocrinology
    • Immunology
    • Pathology

    Background:

    • Lymphocytic adenohypophysitis (LAH) is a rare inflammatory condition affecting the pituitary gland.
    • LAH predominantly affects women, typically during pregnancy or postpartum.
    • Fewer than 20 cases have been previously reported in medical literature.

    Purpose of the Study:

    • To report the first documented case of lymphocytic adenohypophysitis in a male patient.
    • To describe the clinical presentation, diagnostic findings, and immunological markers in this unique case.
    • To discuss the implications of LAH occurring in a male patient.

    Main Methods:

    • Case report of a male patient presenting with symptoms of anterior hypopituitarism.
    • Radiological assessment using computed tomography (CT) to identify an intrasellar mass.

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  • Immunological investigations including antipituitary and antinuclear antibody testing.
  • Human Leukocyte Antigen (HLA) typing.

    • Main Results:

    • The patient presented with anterior hypopituitarism and an intrasellar mass on CT scan.
    • Antipituitary antibodies were absent, but low-titer antinuclear antibodies were detected.
    • The patient's HLA type was A2, B8, Bw58, DR1, and DR5.
    • The severity of pituitary failure appeared disproportionate to the observed mass size on CT.

    Conclusions:

    • Lymphocytic adenohypophysitis can occur in male patients, challenging the previously established female predominance.
    • The absence of antipituitary antibodies and presence of antinuclear antibodies in this male case warrant further investigation.
    • The findings highlight the need for broader diagnostic considerations for hypopituitarism and intrasellar masses, irrespective of sex.