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Updated: Oct 9, 2025
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Quantification of Plasmid-Mediated Antibiotic Resistance in an Experimental Evolution Approach
Published on: December 14, 2019
14.2K
Bacteria can be selected to help beneficial plasmids spread
Tatiana Dimitriu1, Dusan Misevic2, Ariel B Lindner2
1Environment and Sustainability Institute, Biosciences, University of Exeter, Penryn, United Kingdom.
Plos Biology
|December 21, 2021
Summary
Selection can favor chromosomal alleles increasing plasmid donation rates. This study responds to recent commentary questioning the model and assumptions of previous research.
Area of Science:
- Microbiology
- Evolutionary Biology
- Genetics
Background:
- A previous study indicated that natural selection may favor chromosomal alleles that enhance plasmid donation frequencies.
- A recent commentary has raised questions regarding the specific model and assumptions employed in that prior research.
Purpose of the Study:
- To address and refute concerns raised in a recent commentary.
- To reaffirm the validity of the original study's findings on selection and plasmid donation.
Main Methods:
- Re-evaluation of the original model and assumptions.
- Theoretical analysis of evolutionary dynamics.
- Mathematical modeling of genetic selection.
Main Results:
- The authors defend the robustness of their original model.
- Concerns raised in the commentary are addressed and found to be unsubstantiated.
- The original conclusion that selection can favor alleles conferring higher plasmid donation rates is upheld.
Conclusions:
- The original findings remain valid despite the commentary.
- Selection acting on chromosomal alleles influencing plasmid transfer is a significant evolutionary factor.
- Further research may explore the empirical implications of these findings.
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