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Sleep apnoea and cognitive impairment: myth or reality?
1Sorbonne University, CNRS, UMR 8256 Biological Adaptation and Aging, Paris, France, Assistance publique-Hôpitaux de Paris (AP-HP), groupe hospitalier Pitié-Salpêtrière-Charles-Foix, hôpital Charles-Foix, explorations fonctionnelles du sujet âgé, Ivry-sur-Seine, France, Sorbonne University, UFR de médecine, Paris, France.
Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) is common in Alzheimer's disease (AD) patients and may impact cognition. Early detection and treatment of OSAHS could potentially improve cognitive function in individuals with AD.
Area of Science:
- Neurology
- Sleep Medicine
- Gerontology
Background:
- Alzheimer's disease (AD) lacks curative treatments, necessitating focus on comorbidities.
- Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) is a frequent, treatable comorbidity associated with cognitive impairment.
- OSAHS is more prevalent in older AD patients than in cognitively normal individuals and may precede AD development.
Purpose of the Study:
- To review the association between OSAHS and Alzheimer's disease.
- To highlight the importance of OSAHS detection and management in AD patients.
Main Methods:
- Literature review of studies investigating the link between OSAHS and AD.
- Analysis of the impact of OSAHS on cognition and AD biomarkers.
Main Results:
- OSAHS is frequently observed in AD patients and is linked to cognitive decline.
- While OSAHS treatment may not alter AD progression, it shows potential for cognitive improvement in affected AD patients.
- Evidence suggests a connection between OSAHS and AD biomarkers.
Conclusions:
- Detecting and treating OSAHS in AD patients is crucial.
- Managing OSAHS may offer benefits for cognitive function in the context of Alzheimer's disease.
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