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Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants - China, 2021
Kangguo Li1, Zeyu Zhao1,2, Hongjie Wei1
1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China.
Introduction:
Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China. The study aims to estimate effectiveness of booster vaccines for high-risk populations (HRPs).
Methods:
A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed (SEIAR) model was developed to simulate scenarios of effective reproduction number (R ) from 4 to 6. Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.
Results:
Our model showed that we could not prevent outbreaks when covering 80% of HRPs with booster unless R =4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%. The results were consistent when the outcome index was confirmed cases or asymptomatic cases.
Conclusions:
An ideal coronavirus disease 2019 (COVID-19) booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China. Accordingly, the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups.
