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A Rare Bird: Diagnosis of Psittacosis Meningitis by Clinical Metagenomic Next-Generation Sequencing

K Davar1, M R Wilson2, S Miller3,4

  • 1Department of Medicine, Division of Infectious Diseases, University of California Los Angeles, Los Angeles, California, USA.

Open Forum Infectious Diseases
|December 22, 2021
PubMed

Insights

Psittacosis, a rare infectious disease caused by Chlamydia psittaci, is often underdiagnosed. Clinical metagenomic next-generation sequencing offers a promising method for diagnosing this uncommon syndrome.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Genomics

Background:

  • Psittacosis is a zoonotic disease caused by Chlamydia psittaci.
  • It typically manifests as a pulmonary infection but can present as disseminated disease.
  • Underreporting is common due to infrequent pathogen-specific testing.

Purpose of the Study:

  • To highlight the diagnostic challenges of psittacosis.
  • To explore the utility of clinical metagenomic next-generation sequencing (mNGS) for diagnosing uncommon psittacosis presentations.

Main Methods:

  • Review of psittacosis cases and diagnostic approaches.
  • Evaluation of clinical metagenomic next-generation sequencing as a diagnostic tool.

Main Results:

  • Psittacosis is frequently underdiagnosed, leading to underreporting.
  • Clinical metagenomic next-generation sequencing shows potential for identifying Chlamydia psittaci in complex cases.

Conclusions:

  • Accurate diagnosis of psittacosis is crucial for patient management.
  • Clinical metagenomic next-generation sequencing may improve the diagnosis of rare and disseminated psittacosis syndromes.
Keywords:
Chlamydia Psittaciclinical metagenomic next-generation sequencingmeningitispsittacosiszoonotic infection

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