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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
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Central retinal vein occlusion post-COVID-19 vaccination
Nikita J Sonawane1, Divya Yadav1, Annaji Rao Kota1
1Vitreo-Retina Services, Aravind Eye Hospital, Thavalakuppam, Pondicherry, India.
Indian Journal of Ophthalmology
|December 23, 2021
Summary
Two patients experienced central retinal vein occlusion after their second Covishield vaccine dose. Ophthalmologists should monitor for this potential adverse reaction following COVID-19 vaccination.
Area of Science:
- Ophthalmology
- Vaccinology
- Hematology
Background:
- Coronavirus disease 2019 (COVID-19) is associated with thromboembolic events and acute respiratory distress syndrome (ARDS).
- Widespread vaccination campaigns are underway globally, utilizing vaccines such as AZD1222 (ChAdO × 1).
- Post-vaccination thrombotic events have been reported with the AZD1222 vaccine.
Observation:
- Two cases of central retinal vein occlusion (CRVO) are presented.
- These events occurred immediately following the second dose of the Covishield vaccine (a specific formulation of AZD1222).
Findings:
- The presented cases highlight a potential association between Covishield vaccination and the occurrence of CRVO.
- While a causal relationship is not definitively established, the temporal proximity suggests a possible link.
Implications:
- Ophthalmologists should be aware of the potential for CRVO as an adverse reaction to COVID-19 vaccines.
- Further investigation is warranted to understand the mechanisms and incidence of vaccine-associated retinal vascular events.
- This awareness may aid in early diagnosis and management of post-vaccination ocular complications.
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