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Refractory primary extramedullary plasmacytoma in kidney: a case report
Wenjie Niu1, Lili Zhang2, Yuhai Wu1
1Department of Urology, 562131Binzhou Medical University Hospital, Binzhou Medical University Hospital, Binzhou City, China.
The Journal of International Medical Research
|December 23, 2021
Summary
Extramedullary plasmacytoma (EMP), a rare plasma cell neoplasm, rarely presents in renal tissues. This case highlights the challenges in diagnosing and treating refractory renal EMP, ultimately leading to patient mortality.
Area of Science:
- Oncology
- Nephrology
Background:
- Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm, predominantly affecting the upper aerodigestive tract (80-90% of cases).
- Primary renal involvement by EMP is exceptionally rare, posing diagnostic and therapeutic challenges.
Observation:
- A case of a 53-year-old male with refractory primary extramedullary plasmacytoma involving renal tissue is presented.
- The patient underwent radical nephrectomy and radiotherapy, followed by a relapse within 3 months.
Findings:
- Despite initial treatment, the patient experienced disease relapse.
- The renal plasmacytoma cells demonstrated sensitivity to subsequent chemotherapy.
- The patient ultimately succumbed to an infection secondary to the disease after approximately 3.5 years.
Implications:
- This case underscores the extreme rarity of primary renal extramedullary plasmacytoma.
- It highlights the complex management of refractory cases and the potential for treatment resistance.
- The case emphasizes the critical importance of managing complications, such as infection, in patients with rare cancers.
