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Computer-Guided Bone Biopsy: A Technical Note with the Description of a Clinical Case
Federica Altieri1, Giovanna Iezzi2, Valeria Luzzi1
1Department of Oral and Maxillofacial Sciences, School of Dentistry, "Sapienza" University of Rome, 00100 Rome, Italy.
Bioengineering (Basel, Switzerland)
|December 23, 2021
Summary
This technical note introduces a computer-aided design-computer-aided manufacturing (CAD-CAM) surgical guide for precise, computer-guided bone biopsies. This method enhances accuracy and minimizes risks associated with traditional trephine bur use in jawbone diagnostics.
Area of Science:
- Oral Surgery
- Biotechnology
- Medical Device Design
Background:
- Traditional bone biopsies for jawbone diagnostics rely on surgeon skill, risking inaccurate trephine bur placement.
- Computer-aided design-computer-aided manufacturing (CAD-CAM) offers potential for improved precision in surgical procedures.
Purpose of the Study:
- To present a novel CAD-CAM surgical guide for computer-guided bone biopsy.
- To enhance the accuracy and minimize risks of jawbone biopsies.
Main Methods:
- Acquiring stereolithography (STL) files from cone-beam computed tomography (CBCT) and dental casts.
- Superimposing STL files using planning software to design a virtual surgical guide.
- Manufacturing the surgical guide using 3D printing based on determined sampling sites and dimensions.
Main Results:
- The CAD-CAM surgical guide enables a precise and minimally invasive bone biopsy.
- Accurate three-dimensional localization of the biopsy site is achieved.
Conclusions:
- The developed CAD-CAM surgical guide offers high precision, predictability, and efficiency.
- This minimally invasive approach is promising, but further clinical trials are needed to assess benefits and complications.

