Marine Indole Alkaloids-Isolation, Structure and Bioactivities.

Area of Science:

• Natural Products Chemistry
• Marine Biology
• Medicinal Chemistry

Background:

• Indole alkaloids are vital heterocyclic natural products with significant pharmacological potential.
• Marine environments yield structurally diverse indole alkaloids with unique bioactivities.
• This review builds upon previous work, focusing on recent advancements in marine indole alkaloids.

Purpose of the Study:

• To comprehensively review marine indole alkaloids reported between 2015 and 2021.
• To categorize new and structure-revised compounds by their marine sources.
• To highlight the structural diversity and bioactivities of these compounds for drug discovery.

Main Methods:

• Systematic literature search for marine indole alkaloids published from 2015-2021.
• Categorization of compounds based on their origin: marine microorganisms, invertebrates, and plants.
• Compilation and analysis of structural features and reported bioactivities.

Main Results:

• A total of 472 new or structure-revised marine indole alkaloids were identified.
• Compounds were sourced from marine microorganisms, invertebrates, and associated plants.
• Diverse structures and a range of bioactivities were documented for these alkaloids.

Conclusions:

• Marine indole alkaloids represent a rich source for novel drug leads.
• The documented structures and bioactivities facilitate further synthetic and pharmacological studies.
• Continued exploration of marine indole alkaloids is crucial for advancing clinical drug development.