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Comparison of 6 equations for estimating glomerular filtration rate in a Chinese benign hypertensive nephrosclerosis

Guibao Ke1,2,3, Zhibin Xie4, Jie Xiao1

  • 1Department of Nephrology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.

Medicine
|December 23, 2021
PubMed

Insights

The American abbreviated Modification of Diet in Renal Disease (MDRD) equation is suitable for estimating glomerular filtration rate (eGFR) in Chinese patients with benign hypertensive nephrosclerosis (BHN). This equation showed no significant difference compared to measured GFR, unlike other tested formulas.

Area of Science:

  • Nephrology
  • Renal Physiology
  • Hypertension Research

Background:

  • Glomerular filtration rate (GFR) estimation is crucial for monitoring renal status in benign hypertensive nephrosclerosis (BHN).
  • Various equations exist to estimate GFR, but their applicability varies across different populations.

Purpose of the Study:

  • To compare the performance of six different equations for estimating GFR in a Chinese population with BHN.
  • To identify the most suitable GFR estimation equation for this specific patient group.

Main Methods:

  • Compared six GFR estimation equations: Cockcroft-Gault (CG), CG adjusted for body surface area, original Modification of Diet in Renal Disease (MDRD), American abbreviated MDRD, Chinese modified MDRD, and Chronic Kidney Disease Epidemiology (CKD-EPI).
  • Used dual-plasma sampling technetium-labeled diethylenetriaminepentaacetic acid method for reference GFR (rGFR) measurement.
  • Analyzed deviation, absolute deviation, deviation degree, precision, and accuracy of each equation against rGFR in 179 BHN patients.

Main Results:

  • The American abbreviated MDRD equation showed no statistically significant difference in eGFR compared to rGFR (P=.191).
  • Other equations (CG, original MDRD, Chinese modified MDRD, Chinese abbreviated MDRD, CKD-EPI) significantly underestimated or overestimated rGFR.
  • The American abbreviated MDRD equation demonstrated superior performance in deviation, precision, and accuracy compared to other equations.

Conclusions:

  • The American abbreviated MDRD equation is a suitable tool for estimating GFR in Chinese patients with benign hypertensive nephrosclerosis.
  • This finding aids in more accurate renal status monitoring for BHN patients in this demographic.

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