Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

19
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
19
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

19
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
19
Dosage Interval and Administration Route: Determination Methods01:19

Dosage Interval and Administration Route: Determination Methods

14
A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to...
14
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

8
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
8
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

10
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
10
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

14
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
14

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Person-centred care models for institutionalised older adults requiring palliative care: an integrative review.

BMC geriatrics·2026
Same author

Mapping the implementation of adult psychiatric home hospitalization services: a scoping review protocol.

JBI evidence synthesis·2026
Same author

A Multi-Framework Approach to Medication Adherence Evaluation in Pharmacy Student-Led Medication Reviews: An Observational Exploratory Study.

Pharmacy (Basel, Switzerland)·2026
Same author

Work-life balance satisfaction and gender equity within Portuguese community pharmacies staff: findings from a cross-sectional study.

The International journal of pharmacy practice·2026
Same author

Psychotropic deprescribing across different prescribing professions in New Mexico and Louisiana.

PLOS mental health·2026
Same author

Hospital Pharmacists' Perspectives on Documenting and Classifying Pharmaceutical Interventions: A Nationwide Validation Study in Portugal.

Pharmacy (Basel, Switzerland)·2025

Related Experiment Video

Updated: Oct 9, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.7K

Prescribing-Assessment Tools for Long-Term Care Pharmacy Practice: Reaching Consensus through a Modified RAND/UCLA

João R Gonçalves1, Betsy L Sleath2, Manuel J Lopes3

  • 1iMed.ULisboa, Social Pharmacy Department, Faculty of Pharmacy, University of Lisbon, 1649-003 Lisboa, Portugal.

Pharmacy (Basel, Switzerland)
|December 23, 2021
PubMed
Summary

Pharmacists can optimize medication use in long-term care facilities using prescribing-assessment tools. Nine of 24 tools were deemed appropriate, with alternatives to inappropriate medications being a valued feature.

Keywords:
RAND/UCLAconsensuslong-term carepharmacistpharmacy practicepotentially inappropriate prescribingprescribing-assessment tools

More Related Videos

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

18.6K
Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

13.0K

Related Experiment Videos

Last Updated: Oct 9, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.7K
Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

18.6K
Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

13.0K

Area of Science:

  • Geriatric Pharmacy
  • Health Services Research
  • Medication Safety

Background:

  • Medicines are the primary health technology in Long-Term Care (LTC).
  • Potentially inappropriate medication (PIM) use is prevalent among LTC patients.
  • Pharmacists are crucial for optimizing medication management in LTC settings.

Purpose of the Study:

  • To evaluate the suitability of prescribing-assessment tools for pharmacy practice in institutional LTC settings.
  • To identify characteristics and barriers associated with the use of these tools.

Main Methods:

  • A modified RAND/UCLA Appropriateness Method was employed.
  • Thirteen LTC and hospital pharmacists assessed 24 prescribing-assessment tools.
  • Qualitative analysis of participant comments identified tool characteristics and usage barriers.

Main Results:

  • Nine out of 24 tools were classified as 'appropriate' for LTC pharmacy practice.
  • Three tools were classified as 'inappropriate'.
  • The indication of alternatives to PIM was the most appreciated feature.

Conclusions:

  • Prescribing-assessment tools can aid pharmacists in optimizing medication use in LTC.
  • Key barriers to tool implementation include time constraints, pharmacist shortages, and limited clinical information access.