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Published on: August 8, 2019
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[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging.
Tanuj Puri1, Michelle L Frost2, Gary J Cook3
1Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Tomography (Ann Arbor, Mich.)
|December 23, 2021
Summary
Dynamic [18F]NaF PET scans provide kinetic parameters to understand bone physiology. These parameters can serve as imaging biomarkers for early detection of drug treatment responses in clinical trials.
Area of Science:
- Nuclear medicine
- Pharmacokinetics
- Bone physiology
Background:
- Dynamic positron emission tomography (PET) scans offer insights into physiological processes.
- Sodium fluoride ([18F]NaF) is a radiotracer used in PET imaging.
- The Hawkins model is employed to analyze pharmacokinetic data.
Purpose of the Study:
- To highlight the significance of kinetic parameters derived from dynamic [18F]NaF PET scans.
- To demonstrate the utility of these parameters in understanding bone physiology.
- To explore the potential of dynamic [18F]NaF PET as an imaging biomarker in drug development.
Main Methods:
- Acquisition of dynamic [18F]NaF PET scans.
- Analysis of PET data using the Hawkins pharmacokinetic model.
- Quantification of kinetic parameters (k-values).
Main Results:
- Kinetic parameters (k-values) were successfully obtained from dynamic [18F]NaF PET scans.
- These parameters provide a quantitative measure related to bone physiology.
- The analysis demonstrates the feasibility of using this method.
Conclusions:
- Kinetic parameters from dynamic [18F]NaF PET scans are significant for understanding bone physiology.
- Dynamic [18F]NaF PET imaging shows promise as a biomarker in early-phase clinical trials.
- This approach may aid in the early detection of treatment responses, potentially reducing late-stage drug attrition.
