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Updated: Jun 26, 2026
06:34
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Age-Related Concentric Remodeling and Sex-Dependent Dimensional Variation in Left Ventricular Geometry: A Cardiac
Davut Unsal Capkan1, Mehmet Kaplan2
1Department of Radiology, Medical Point Hospital, 27060 Gaziantep, Turkey.
Tomography (Ann Arbor, Mich.)
|June 25, 2026
Summary
Advancing age is linked to proportional left ventricular (LV) geometric remodeling, while male sex influences absolute LV dimensions. Standard cardiac MRI measurements can identify these age-related changes.
Area of Science:
- Cardiology
- Medical Imaging
- Human Physiology
Background:
- Left ventricular (LV) geometry adapts to aging and sex.
- Cardiac magnetic resonance (CMR) offers precise assessment but often focuses on volumetric data.
- Linear indices from standard CMR reports are underutilized for evaluating age and sex influences on LV structure.
Purpose of the Study:
- To assess the impact of age and sex on LV geometry.
- To utilize standard CMR linear indices like wall thickness and LV end-diastolic diameter (LVEDD).
- To investigate proportional indices such as relative wall thickness (RWT) and wall thickness-to-LVEDD ratio (WT/LVEDD).
Main Methods:
- Retrospective cross-sectional study of 95 adult patients undergoing CMR.
- Analysis of LV wall thickness, LVEDD, RWT, and WT/LVEDD ratio.
- Stratification by sex and age groups (18-40, 41-60, >60 years) with statistical comparisons.
Main Results:
- Males exhibited significantly larger LVED and greater LV wall thickness.
- Age positively correlated with mean LV wall thickness and WT/LVEDD ratio.
- Age independently predicted concentric remodeling (OR=1.041 per year), while male sex predicted larger LVED.
Conclusions:
- Advancing age is independently associated with proportional LV geometric remodeling.
- Male sex primarily influences absolute ventricular dimensions.
- Standardized linear CMR measurements effectively detect age-related concentric remodeling in clinical practice.
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