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Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

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Related Experiment Video

Updated: Oct 9, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

DNA Nanodevice-Based Drug Delivery Systems.

Chaoyang Guan¹, Xiaoli Zhu^1,2, Chang Feng¹

¹Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, China.

|December 24, 2021

Summary

This summary is machine-generated.

DNA nanodevices offer programmable, smart-responsive solutions for precise tumor treatment. This review highlights advancements in DNA materials for targeted drug delivery and elimination, paving the way for future biomedical applications.

Keywords:

DNA framework controllable release drug delivery nanodevice stimuli response

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Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

DNA's inherent biocompatibility, synthesizability, and programmability make it a prime material for biomedical applications.
Advancements in DNA understanding and technology have enabled the development of smart-responsive DNA nanodevices.
These nanodevices can be engineered to respond to specific stimuli for targeted functions.

Purpose of the Study:

To review the progress of DNA-based nanodevices in biomedical applications over the past decade.
To highlight the potential of DNA nanodevices for tumor treatment, focusing on precise targeting and drug delivery.
To provide insights into future development directions for DNA materials in medicine.

Main Methods:

Review of scientific literature focusing on DNA nanotechnology and its biomedical applications.
Analysis of recent advancements in DNA synthesis, modification, and smart-responsive nanodevice design.
Exploration of case studies demonstrating DNA nanodevices in tumor treatment contexts.

Main Results:

DNA materials have evolved into sophisticated, smart-responsive nanodevices for biomedical applications (version 2.0).
These nanodevices show promise in addressing challenges in tumor treatment, including precise targeting and controlled drug release.
Significant progress has been made in harnessing DNA's properties for functional biomedical tools.

Conclusions:

DNA nanodevices represent a significant advancement in materials science for targeted therapies.
Further research and development in DNA nanotechnology are expected to yield innovative solutions for complex diseases like cancer.
The programmability of DNA offers vast potential for future personalized and precision medicine.