Related Experiment Video
Updated: Oct 9, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease-Preliminary Report
Tomasz Urbanowicz1, Michał Michalak2, Anna Olasińska-Wiśniewska1
1Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
Insights
Hematologic indices, including monocyte to lymphocyte ratio (MLR) and mean corpuscular hemoglobin concentration (MCHC), can predict severe carotid artery disease. Elevated MLR and MCHC levels indicate a higher likelihood of collateral carotid stenosis, aiding in atherosclerosis assessment.
Area of Science:
- Vascular Surgery
- Hematology
- Cardiovascular Disease
Background:
- Carotid artery disease is a significant cause of ischemic stroke.
- Biomarkers are crucial for predicting stroke progression and severity.
- Severe carotid disease necessitates surgical intervention.
Purpose of the Study:
- To compare hematologic indices in patients with severe carotid disease.
- To identify predictive markers for collateral carotid stenosis.
Main Methods:
- Retrospective study of 135 patients undergoing surgical carotid intervention.
- Analysis of hematologic indices, including monocyte to lymphocyte ratio (MLR) and mean corpuscular hemoglobin concentration (MCHC).
- Statistical analysis using Mann-Whitney test and logistic regression.
Main Results:
- Significant differences in MLR and MCHC were found between patients with single and multiple (collateral) carotid diseases.
- MLR > 0.3 (AUC=0.654) and MCHC > 21.6 (AUC=0.730) showed predictive value.
- Logistic regression identified MLR > 0.3 (OR=6.19) and MCHC > 21.6 (OR=7.76) as significant predictors for collateral carotid stenosis.
Conclusions:
- Elevated MLR and MCHC levels are valuable predictors of collateral carotid stenosis.
- These hematologic indices can serve as accessible indicators of atherosclerosis severity.
- MLR and MCHC may assist in risk stratification for patients with carotid artery disease.
Background:
Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients referred for surgical interventions due to severe carotid disease.
Methods:
In total, 135 patients (87 (64.4%) men and 48 (35.6%) women) with a mean age of 70 ± 8 years who underwent surgical carotid intervention were enrolled into the study.
Results:
A Mann-Whitney test for independent samples revealed significant differences in monocyte to lymphocyte ratio (MLR) and mean corpuscular hemoglobin concentration (MCHC) between patients with one and two (collateral) carotid diseases. The cut-off value for MLR was 0.3 (AUC = 0.654, p = 0.048, 70.0% sensitivity and 74.6% specificity) and for MHCH was 21.6. (AUC = 0.730, p < 0.001, 70.0% sensitivity and 77.2% specificity). A multivariable model of logistic regression revealed two significant parameters for collateral carotid stenosis disease including MLR > 0.3 (OR 6.19 with 95% CI 2.02-19.01, p = 0.001) and MCHC > 21.6 (OR 7.76, 95% CI 2.54-23.72, p < 0.001).
Conclusions:
MLR above 0.3 and MCHC above 21.6 have predictive values for colleterial carotid stenosis and may be used as easily accessible indicators for atherosclerosis severity.
More Related Videos
07:25Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
09:41Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
Published on: October 17, 2017
