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Updated: Oct 9, 2025

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
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Published on: May 2, 2025

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Formation of the Codon Degeneracy during Interdependent Development between Metabolism and Replication

Dirson Jian Li1

  • 1Ministry of Education Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic Physics, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China.

Genes
|December 24, 2021
PubMed
Summary

This study explains the origin of codon degeneracy, a key feature of the genetic code. It proposes that base pair stability drove nonrandom prebiotic evolution, assigning codons to amino acids.

Keywords:
coevolution of tRNAs with aaRSsrelative stability of triplex base pairthe codon degeneracythe evolution of the genetic code

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