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Conjugated Proteins

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...

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Related Experiment Video

Updated: Oct 9, 2025

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

Protein-Based Nanoparticle Vaccines for SARS-CoV-2.

Hyo-Dong Sung¹, Nayeon Kim¹, Yeram Lee¹

¹Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, Daegu 41566, Korea.

International Journal of Molecular Sciences

|December 24, 2021

Summary

Protein-based nanoparticle vaccines offer a promising strategy against SARS-CoV-2, enhancing immune responses through multivalent antigen presentation. This review highlights innovations and clinical progress in these advanced COVID-19 vaccine candidates.

Keywords:

SARS-CoV-2 nanomedicine nanovaccine protein nanoparticles protein-based nanotechnology vaccines

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Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

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Published on: August 13, 2021

Area of Science:

Vaccinology
Structural Biology
Immunology

Background:

The COVID-19 pandemic, caused by SARS-CoV-2, necessitated rapid vaccine development.
Existing vaccines have shown efficacy, but novel approaches are continuously explored.
Protein-based nanoparticles offer advantages for antigen presentation and immune stimulation.

Purpose of the Study:

To review recent innovations in protein-based nanoparticle vaccines against SARS-CoV-2.
To highlight design strategies for displaying SARS-CoV-2 antigens on nanoparticles.
To summarize the performance and clinical trial progress of these vaccines.

Main Methods:

Review of recent scientific literature on SARS-CoV-2 protein-based nanoparticle vaccines.
Analysis of strategies for antigen display (spike protein, RBD) on various nanoparticle platforms.
Summary of preclinical and clinical trial data for developed vaccines.

Main Results:

Various protein-based nanoparticle platforms are being investigated for SARS-CoV-2 vaccine development.
Successful display of key antigenic domains (e.g., RBD) on nanoparticles enhances immunogenicity.
Several candidates show potent humoral and cellular immune responses in preclinical studies.

Conclusions:

Protein-based nanoparticle vaccines represent an innovative strategy for combating SARS-CoV-2.
These platforms facilitate multivalent antigen presentation, leading to robust immune responses.
Further clinical evaluation is ongoing, with a promising outlook for this vaccine technology.