Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression-3PM
Peter Kubatka1, Alena Mazurakova2, Marek Samec3
1Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
The EPMA Journal
|December 24, 2021
Summary
Flavonoids exhibit anti-inflammatory properties that can help prevent and treat cancer by targeting pro-inflammatory pathways. Personalized medicine approaches are key for effective flavonoid-based cancer prevention strategies.
Area of Science:
- Molecular Biology
- Immunology
- Oncology
Background:
- Chronic inflammation is a key factor in cancer initiation and progression.
- It causes molecular and cellular changes that promote tumor growth and metastasis.
- Flavonoids possess anti-inflammatory properties with potential in cancer prevention and therapy.
Purpose of the Study:
- To analyze the anti-inflammatory properties of flavonoids.
- To highlight their mechanisms and targeted molecular pathways in cancer.
- To propose treatment models for cancer prevention within personalized medicine.
Main Methods:
- In-depth analysis of scientific literature on flavonoid anti-inflammatory effects.
- Review of molecular mechanisms and signaling pathways targeted by flavonoids.
- Exploration of predictive, preventive, and personalized medicine (PPPM) frameworks.
Main Results:
- Flavonoids modulate pro-inflammatory gene expression.
- They target key molecular pathways involved in carcinogenesis.
- Individualized patient profiling is essential for targeted anti-inflammatory treatments.
Conclusions:
- Flavonoids are promising agents for cancer prevention and therapy due to their anti-inflammatory actions.
- Targeted anti-inflammatory strategies based on flavonoids can be integrated into personalized cancer management.
- Further research into flavonoid mechanisms and clinical applications is warranted.
Keywords:
CancerCancer initiationCancer progressionCancer promotionCarcinogenesisCytokinesDNA damageFlavonoidsHIF-1αIL-1βIL-6IL-8Impaired healingInflammationInflammatory pathwayLow-grade systemic inflammationMatrix metalloproteinasesMolecular targetsNF-κB signalingNatural substancesPhytochemicalsPre-metastatic nichesPredictive preventive personalized medicine (PPPM / 3PM)ROSS100Systemic hypoxic-ishemic effectsTNF-αTissue remodeling
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