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Clinical Problem Solving: An Older Woman With Weakness from Head to Toe
David A Hartmann1, Meredith Bock2, Vanja Douglas2
1Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Abstract:
A 67-year-old woman was admitted to our hospital for progressive weakness, dysphagia, muscle pain, and weight loss. Here we detail the clinical problem solving involved in diagnosing and treating her immune-mediated necrotizing myopathy caused by anti-HMGCoA reductase autoantibodies. Interestingly, this diagnosis coincided with discovery of a gastrointestinal stromal tumor (GIST) and positivity for anti-nuclear matrix protein (anti-NXP2), another myositis specific autoantibody.
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