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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Targeted drug delivery strategies for precision medicines

Mandana T Manzari1,2, Yosi Shamay3,2, Hiroto Kiguchi4,5,2

  • 1Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature Reviews. Materials
|December 24, 2021
PubMed

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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