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Differences in complications between hepatitis B-related cirrhosis and alcohol-related cirrhosis

Yu-Pei Zhuang1, Si-Qi Wang1, Zhao-Yu Pan1

  • 1Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19 Nonglinxialu, Guangzhou 510000, Guangdong Province, China.

Open Medicine (Warsaw, Poland)
|December 24, 2021
PubMed

Insights

Hepatitis B virus (HBV)-related cirrhosis increases risks of liver cancer and enlarged spleen. Alcohol-related cirrhosis more often leads to brain and liver failure complications. Different causes yield distinct cirrhosis outcomes.

Area of Science:

  • Hepatology and Gastroenterology
  • Viral Hepatitis Research
  • Alcohol-Induced Liver Disease

Background:

  • Cirrhosis is advanced liver scarring from various causes.
  • Hepatitis B virus (HBV) and alcohol abuse are leading causes of cirrhosis worldwide.
  • Understanding etiological differences in complication profiles is crucial for patient management.

Purpose of the Study:

  • To compare the specific complication rates and risks between HBV-related and alcohol-related cirrhosis.
  • To identify distinct patterns of complications based on cirrhosis etiology.

Main Methods:

  • Retrospective review of medical records for patients diagnosed with HBV-related or alcohol-related cirrhosis between January 2014 and January 2021.
  • Assessment of unadjusted complication rates and adjusted risks using statistical analysis.

Main Results:

  • HBV-related cirrhosis showed higher rates of hepatocellular carcinoma (HCC) and hypersplenism.
  • Alcohol-related cirrhosis was associated with higher rates of hepatic encephalopathy (HE) and acute-on-chronic liver failure (ACLF).
  • Adjusted analyses confirmed significantly higher risks for HCC and hypersplenism in HBV-related cirrhosis, and for HE and ACLF in alcohol-related cirrhosis.

Conclusions:

  • Cirrhosis complications vary significantly based on their underlying cause (HBV vs. alcohol).
  • HBV-related cirrhosis poses a greater risk for developing HCC and hypersplenism.
  • Alcohol-related cirrhosis is more strongly linked to HE and ACLF development.
Abstract

Keywords:
alcoholismhepatitis B virusliver cirrhosispatients

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