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Quantitative proteomics revealed new functions of ALKBH4

Kailin Yu1, Tianyu F Qi2, Weili Miao1

  • 1Department of Chemistry, University of California, Riverside, California, USA.

Proteomics
|December 24, 2021
PubMed
Summary

ALKBH4 demethylase regulates DNA methylation. Its absence increases DNA (cytosine-5)-methyltransferase 1 (DNMT1), reducing GSTP1 and HSPB1 protein levels by altering gene promoter methylation.

Keywords:
SILACbisulfite sequencingcytosine methylationmass spectrometryparallel-reaction monitoringpost-translational modificationquantitative proteomics

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