Sulfur functionality-modified starches: Review of synthesis strategies, properties, and applications

Starch is the second most abundant naturally-occurring polymer after cellulose that possess superior physicochemical and biological features with numerous practical applications ranging from industrial to biomedical. Despite, native starch suffer from some drawbacks, including difficult processability, low shear and thermal stability, weak mechanical properties, and tendency to easily retrograde and undergo syneresis. Therefore, modification of native starch is necessary for circumvent the above-mentioned problems and expanding application ranges. This natural polymer can be modified using chemical, physical, enzymatic, and genetic engineering strategies. Amongst, chemical approaches have received more attention owing to enhancing physicochemical and biological features that lead to higher performance than those of the other strategies. In this context, incorporation of sulfur functionality-containing groups (sulfonation and sulfation) can be considered as an efficient approach due to significant enhancement in physiochemical properties, including zeta potential (move to negative values), molecular weight, processiability (e.g., solubility and meltability), and rheology. Furthermore, this strategy can modified some biological features, such as hemocompatibility, protein sorption, biostability, adhesion and proliferation of numerous cells, antithrombogenicity, antiinflammatory, antiviral, antimicrobial, antioxidant, antifungal, anticoagulant and antifouling properties. Accordingly, this review highlight's the synthesis strategies, physiochemical and biological properties, as well as applications of sulfur functionality-modified starches in numerous practical fields.