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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Related Experiment Video

Updated: Oct 8, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Radiotherapy of lymphomas.

J Balosso1, F Missohou1, D Antoni2

  • 1Centre François-Baclesse, BP 45026, 14076 Caen cedex 5, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|December 26, 2021
PubMed
Summary

Radiotherapy remains crucial for early-stage Hodgkin lymphoma, often combined with chemotherapy. Treatment personalization, guided by FDG-PET scans, aims to reduce toxicity while maintaining high cure rates and quality of life.

Keywords:
French society for radiation oncologyGuidelinesHodgkin lymphomaLymphome hodgkinienLymphomes non hodgkiniensNon-Hodgkin lymphomaRadiation therapyRadiothérapieRecommandationsSociété française de radiothérapie oncologique

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Hematology

Background:

  • Radiotherapy is a cornerstone in managing early-stage Hodgkin lymphoma, frequently used alongside chemotherapy.
  • While its role in non-Hodgkin lymphomas is more limited, similar therapeutic principles apply across histological types.
  • Evolving strategies focus on optimizing treatment outcomes and patient quality of life.

Purpose of the Study:

  • To present an updated set of recommendations for radiotherapy in lymphoma management.
  • To highlight the evolving therapeutic strategies and evaluation methods in lymphoma radiotherapy.
  • To emphasize the importance of personalized treatment approaches based on diagnostic assessments.

Main Methods:

  • Review and update of clinical guidelines for radiotherapy in lymphomas.
  • Integration of findings from FDG-PET (fluorodeoxyglucose-positron emission tomography) assessments for treatment personalization.
  • Consideration of both Hodgkin and non-Hodgkin lymphoma treatment paradigms.

Main Results:

  • Radiotherapy plays a vital role in early-stage Hodgkin lymphoma, enhancing cure rates.
  • Personalized radiotherapy, informed by FDG-PET, allows for de-escalation of toxicity.
  • Updated recommendations reflect advancements in therapeutic strategies and evaluation.

Conclusions:

  • Radiotherapy remains integral to Hodgkin lymphoma treatment, particularly in early stages.
  • Personalized treatment de-escalation using FDG-PET is key to improving patient quality of life.
  • Continuous evolution in lymphoma radiotherapy necessitates regular guideline updates.