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Published on: January 5, 2024
Inflammatory Markers in the Diagnosis of Fibromyalgia
Rola Khamisy-Farah1,2, Eliyahu Fund2,3, Shir Raibman-Spector4
1Clalit Health Services, Akko, Israel.
Background:
Fibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain accompanied by various additional symptoms. The prevalence of FMS ranges between 2-8% of the population. The exact pathophysiology of the disease remains unknown, and under certain circumstances it is difficult for the physician to diagnose. Previous studies have shown a correlation between inflammatory biomarkers such as C-reactive protein (CRP) and FMS activity, suggesting that an inflammatory component may play a role in this disease pathogenesis.
Objectives:
To investigate the role of certain new inflammatory biomarkers in the diagnosis of patients with FMS.
Methods:
In this study data were collected from FMS patients who were admitted to Ziv Medical Center during the period 2013 to 2019 in an attempt to find a connection between inflammatory markers detectable by a traditional complete blood count (CBC) tests such as neutrophil-lymphocytes ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet value (MPV), red cell distribution width (RDW), and C-reactive protein (CRP) and FMS.
Results:
We found significantly higher CRP levels, MPV, and PLR and lower lymphocyte count in the FMS group compared to the control group.
Conclusions:
FMS has certain inflammatory components that may be useful in disease diagnosis.
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