The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study

Area of Science:

• Gynecology
• Pathophysiology
• Biochemistry

Background:

• Endometrial hyperplasia (EH) is a significant precursor to endometrial cancer.
• Understanding the molecular mechanisms underlying EH is crucial for early detection and prevention.

Purpose of the Study:

• To investigate the role of oxidative stress and thiol groups in the pathogenesis of endometrial hyperplasia.
• To compare oxidative stress markers between patients with EH and healthy controls.

Main Methods:

• A prospective case-control study involving endometrial biopsies.
• Analysis of thiol and disulfide levels in endometrial washing fluid using the Ellman reagent.
• Comparison of biochemical markers between 108 EH patients and 84 control participants.

Main Results:

• Patients with EH exhibited higher levels of disulfide and altered thiol/disulfide ratios compared to controls.
• Total and native thiol levels were significantly lower in the EH group.
• A positive correlation between estradiol and disulfide levels was observed in the control group, but not in the EH group.

Conclusions:

• Elevated oxidative stress, indicated by higher disulfide levels, is implicated in the etiology of endometrial hyperplasia.
• Thiol group dysregulation may contribute to the development of EH.
• These findings highlight the potential of targeting oxidative stress pathways in managing EH.