Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic autoimmune disease arises from polyclonal B cell activation.

D M Klinman, A D Steinberg

    The Journal of Experimental Medicine
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anti-Ia antibodies: a revolutionary therapy for immune-mediated diseases?

    Immunology today·2014
    Same author

    The basis of autoimmunity in MRL-lpr/lpr mice: a role for self Ia-reactive T cells.

    Immunology today·2014
    Same author

    Mitrecin A, an endolysin-like bacteriolytic enzyme from a newly isolated soil streptomycete.

    Letters in applied microbiology·2014
    Same author

    [The effect of Soviet synthetic antimalarial remedies, acriquine and plasmocide, on the nervous system].

    Farmakologiia i toksikologiia·2010
    Same author

    Immune cell cooperation, viruses, and antibodies to nucleic acids in new zealand mice.

    The Journal of experimental medicine·2009
    Same author

    Renal flares are common in patients with severe proliferative lupus nephritis treated with pulse immunosuppressive therapy: long-term followup of a cohort of 145 patients participating in randomized controlled studies.

    Arthritis and rheumatism·2002

    Systemic autoimmune diseases stem from polyclonal B cell activation. Autoimmune and nonautoimmune mice showed similar proportions of antibody-producing B cells, suggesting a widespread immune response.

    Area of Science:

    • Immunology
    • Autoimmunity
    • B cell biology

    Background:

    • Autoimmune diseases are characterized by the immune system attacking self-antigens.
    • The specific mechanisms driving B cell hyperactivity in autoimmunity are not fully understood.

    Purpose of the Study:

    • To compare B cell populations reactive to autoantigens and conventional antigens in autoimmune and nonautoimmune mice.
    • To investigate the role of polyclonal B cell activation in the pathogenesis of systemic autoimmune diseases.

    Main Methods:

    • Single-cell analysis of splenic B cells from NZB, MRL lpr/lpr, and BXSB autoimmune mouse models.
    • Quantification of B cells secreting antibodies against autoantigens and conventional antigens.
    • Comparison of antibody specificities as a percentage of the total B cell repertoire.

    Related Experiment Videos

    Main Results:

    • The proportion of B cells producing antibodies against autoantigens or conventional antigens was similar in autoimmune and congenic nonautoimmune mice.
    • Both autoantigen-reactive and conventional antigen-reactive B cells and serum antibodies increased proportionally.
    • No significant difference was observed in the B cell repertoire composition between the groups.

    Conclusions:

    • Systemic autoimmune diseases are driven by polyclonal B cell activation, not restricted self-reactivity.
    • The findings suggest a common underlying mechanism for B cell hyperactivity in various autoimmune conditions.
    • This indicates a fundamental dysregulation of B cell immunity in autoimmunity.