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Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Myasthenia Gravis: Overview and Treatment01:20

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Related Experiment Video

Updated: Oct 8, 2025

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
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COVID-19-Induced Guillain-Barré Syndrome.

Joseph E Brooks1, Felicia M Mix2, Justin C Buck3

  • 1Physical Medicine and Rehabilitation, Genesis Health System, Davenport, USA.

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|December 27, 2021
PubMed
Summary

A COVID-19 patient developed Guillain-Barré syndrome (GBS), diagnosed as acute inflammatory demyelinating polyradiculoneuropathy (AIDP). Despite IVIG treatment and rehabilitation, the patient had limited mobility post-discharge.

Keywords:
covid 19covid induced guillian barre syndromeelectrodiagnostic studyelectromyography and electro-stimulationguillain-barre syndrome (gbs)

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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
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Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Coronavirus disease 2019 (COVID-19) is a global health concern.
  • Guillain-Barré syndrome (GBS) is a rare neurological disorder.
  • The association between COVID-19 and GBS requires further investigation.

Observation:

  • A 47-year-old male with confirmed COVID-19 presented with GBS symptoms.
  • Electrodiagnostic studies confirmed acute inflammatory demyelinating polyradiculoneuropathy (AIDP).

Findings:

  • The patient received intravenous immune globulin (IVIG) therapy.
  • Four weeks of inpatient rehabilitation yielded partial functional improvement.
  • Independent ambulation was not achieved at discharge.

Implications:

  • This case highlights a potential neurological complication of COVID-19.
  • Early recognition and treatment of GBS in COVID-19 patients are crucial.
  • Further research is needed to understand the pathophysiology and long-term outcomes.