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Related Experiment Video

Updated: Oct 8, 2025

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Cardiac Troponin Is Elevated in Patients with Thyrotoxicosis and Decreases as Thyroid Function Improves and Brain

Natsuko Watanabe1, Jaeduk Yoshimura Noh1, Naomi Hattori1

  • 1Department of Internal Medicine, Ito Hospital, Tokyo, Japan.

European Thyroid Journal
|December 27, 2021
PubMed
Summary
This summary is machine-generated.

Thyrotoxicosis can elevate high-sensitive troponin I (hsTnI) in about 20% of patients, indicating subclinical myocardial injury. hsTnI levels decrease with improved thyroid function and reduced brain natriuretic peptide (BNP).

Keywords:
Brain natriuretic peptideCardiac troponinHeartHyperthyroidismThyrotoxicosis

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Area of Science:

  • Cardiology
  • Endocrinology
  • Biomarker Research

Background:

  • High-sensitive cardiac troponin (hsTnI) serves as a sensitive indicator of myocardial injury, even without overt myocardial infarction.
  • Thyrotoxicosis, a condition of excess thyroid hormones, can impact cardiovascular function and potentially affect cardiac biomarkers.

Purpose of the Study:

  • To investigate the relationship between thyrotoxicosis and elevated levels of high-sensitive troponin I (hsTnI).
  • To determine how hsTnI levels change during the treatment of hyperthyroidism.

Main Methods:

  • Prospective observational study conducted in Japan involving 143 untreated thyrotoxicosis patients.
  • Measurements of thyroid function (free T4), hsTnI, and brain natriuretic peptide (BNP) were taken at baseline and every 3 months for one year.
  • Medical treatment was initiated for hyperthyroidism during the study period.

Main Results:

  • Approximately 20% of patients presented with elevated hsTnI levels at baseline (≥5.0 pg/mL).
  • hsTnI levels were significantly correlated with age and BNP, while BNP was influenced by age, hemoglobin, free T4, and hsTnI.
  • A decrease in hsTnI and BNP was observed within the first 3 months, correlating with improvements in thyroid function (FT4).

Conclusions:

  • Elevated hsTnI is common in patients with thyrotoxicosis, suggesting potential subclinical myocardial strain.
  • hsTnI levels normalize in a majority of affected patients within a year as thyroid function improves.
  • The study highlights the interplay between thyroid status, cardiac biomarkers (hsTnI), and heart strain indicators (BNP).