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Single-cell RNA sequencing: a powerful tool to study heterogeneity in papillary and anaplastic thyroid carcinoma

Vicente Rodrigues Marczyk1,2, Jennifer Rui Wang1

  • 1Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center , Houston, USA.

European Thyroid Journal
|June 24, 2026
PubMed

Keywords:
single-cell sequencingthyroid cancertranscriptometumor microenvironment

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RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...