Related Experiment Video
Updated: Oct 8, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
Testing terror management theory in advanced cancer.
Elsy Willis1, Kenneth Mah1, Gilla K Shapiro1,2
1Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Terror management theory (TMT) suggests that psychological defenses buffer death anxiety. In advanced cancer patients, strong defenses like attachment security, meaning, and self-esteem significantly lowered death anxiety related to physical impairment.
Area of Science:
- Psychology
- Oncology
- Sociology
Background:
- Advanced cancer patients frequently experience heightened death anxiety due to increased mortality salience.
- Terror management theory (TMT) posits that psychological defenses mitigate existential concerns, including death anxiety.
Purpose of the Study:
- To investigate the buffering effect of distal defenses against mortality salience in advanced cancer patients.
- To evaluate the role of attachment security, meaning, and self-esteem in mitigating death anxiety.
Main Methods:
- A study involving 305 advanced cancer patients.
- Assessed the impact of physical impairment (as a proxy for mortality salience) on death anxiety.
- Examined the moderating influence of distal defenses (attachment security, meaning, self-esteem).
Main Results:
- Patients possessing a greater number of strong distal defenses reported significantly lower levels of death anxiety.
- Conversely, patients with few or no strong defenses exhibited higher death anxiety.
Conclusions:
- Findings support the applicability of Terror Management Theory (TMT) in populations confronting imminent mortality.
- Highlights the importance of psychological buffers, such as attachment security, meaning, and self-esteem, in managing death anxiety among cancer patients.
- Suggests avenues for future TMT research in clinical populations facing existential threats.
More Related Videos
Related Concept Videos
Tumor Immunotherapy
The Tumor Microenvironment
Cancer Survival Analysis
Targeted Cancer Therapies
There are several types of targeted therapies against...
Treatment Resistant Cancers

