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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
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Molecular testing for melanocytic tumors: a practical update.
1Departments of Pathology and Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Histopathology
|December 27, 2021
Summary
Molecular assays are transforming melanocytic tumor diagnosis and management. This review categorizes key ancillary tests aiding pathologists in differentiating tumors, predicting melanoma prognosis, and guiding therapy selection.
Area of Science:
- Pathology
- Oncology
- Molecular Diagnostics
Background:
- The diagnosis and management of melanocytic tumors have been significantly impacted by advancements in molecular assays.
- Pathologists face challenges in navigating the increasing number of molecular tests available for clinical use.
Purpose of the Study:
- To provide an updated overview of major ancillary molecular tests used in the clinical practice of melanocytic pathology.
- To categorize molecular tests based on their utility in diagnosis, prognosis, classification, and therapy response prediction.
Main Methods:
- Literature review of current molecular assays in melanocytic pathology.
- Categorization of molecular tests into four main groups based on clinical application.
Main Results:
- Molecular tests are broadly categorized into: (i) nevus versus melanoma differentiation, (ii) melanoma prognosis prediction, (iii) tumor classification, and (iv) prediction of response to systemic therapy.
- These tests serve as crucial aids for practicing pathologists in managing melanocytic tumors.
Conclusions:
- Molecular testing has become indispensable in the work-up of melanocytic tumors.
- Understanding the different categories of molecular assays is essential for optimal clinical application and patient management.
