Related Experiment Video
Updated: Oct 8, 2025
Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
Published on: August 23, 2024
Receptor-Mediated Targeted Delivery of Surface-ModifiedNanomedicine in Breast Cancer: Recent Update and Challenges
Md Rizwanullah1, Mohammad Zaki Ahmad2, Mohammed M Ghoneim3
1Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Abstract:
Breast cancer therapeutic intervention continues to be ambiguous owing to the lack of strategies for targeted transport and receptor-mediated uptake of drugs by cancer cells. In addition to this, sporadic tumor microenvironment, prominent restrictions with conventional chemotherapy, and multidrug-resistant mechanisms of breast cancer cells possess a big challenge to even otherwise optimal and efficacious breast cancer treatment strategies. Surface-modified nanomedicines can expedite the cellular uptake and delivery of drug-loaded nanoparticulate constructs through binding with specific receptors overexpressed aberrantly on the tumor cell. The present review elucidates the interesting yet challenging concept of targeted delivery approaches by exploiting different types of nanoparticulate systems with multiple targeting ligands to target overexpressed receptors of breast cancer cells. The therapeutic efficacy of these novel approaches in preclinical models is also comprehensively discussed in this review. It is concluded from critical analysis of related literature that insight into the translational gap between laboratories and clinical settings would provide the possible future directions to plug the loopholes in the process of development of these receptor-targeted nanomedicines for the treatment of breast cancer.
Insights
Targeted nanomedicines offer improved breast cancer treatment by enhancing drug delivery. Exploiting specific receptors on cancer cells with novel nanoparticulate systems shows promise in preclinical models.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Breast cancer treatment faces challenges due to poor drug targeting, tumor microenvironment, and multidrug resistance.
- Conventional chemotherapy has limitations in efficacy and specificity for breast cancer.
- Developing targeted drug delivery systems is crucial for overcoming these obstacles.
Purpose of the Study:
- To review targeted delivery approaches for breast cancer using nanoparticulate systems.
- To explore the use of multiple targeting ligands for receptor-mediated drug uptake.
- To discuss the therapeutic efficacy of these novel approaches in preclinical models.
Main Methods:
- Review of literature on surface-modified nanomedicines for breast cancer.
- Analysis of nanoparticulate systems with multiple targeting ligands.
- Evaluation of receptor-mediated cellular uptake mechanisms.
Main Results:
- Surface-modified nanomedicines can enhance drug-loaded nanoparticulate construct delivery.
- Targeting overexpressed receptors on breast cancer cells improves cellular uptake.
- Preclinical studies demonstrate the therapeutic efficacy of these targeted approaches.
Conclusions:
- Receptor-targeted nanomedicines show significant potential for breast cancer treatment.
- Addressing the translational gap between laboratory research and clinical application is key.
- Future directions should focus on refining nanomedicine development for clinical success.
