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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Polymeric Nanoparticles Properties and Brain Delivery.

Laís Ribovski1, Naomi M Hamelmann1, Jos M J Paulusse1

  • 1Department of Molecules and Materials, MESA+ Institute for Nanotechnology and TechMed Institute for Health and Biomedical Technologies, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

Pharmaceutics
|December 28, 2021
PubMed
Summary
This summary is machine-generated.

Designing nanoparticles (NPs) is key for effective brain drug delivery. Optimizing NP properties beyond size and shape, like ligand density and stiffness, enhances transport across the blood-brain barrier (BBB) for central nervous system (CNS) therapies.

Keywords:
blood–brain barrierbrain deliverycontrolled drug deliverynanomedicinenanoparticlespolymerstherapeutics

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Area of Science:

  • Nanotechnology
  • Neuroscience
  • Pharmacology

Background:

  • Effective drug delivery to the central nervous system (CNS) is crucial for treating neurological disorders but faces significant challenges.
  • Current therapeutic approaches often have limited success due to difficulties in crossing the blood-brain barrier (BBB).
  • Nanoparticles (NPs) offer a promising strategy for enhanced drug delivery, but their brain penetration requires careful optimization.

Purpose of the Study:

  • To explore how specific nanoparticle (NP) properties influence their ability to cross the blood-brain barrier (BBB) and reach the brain.
  • To highlight the importance of under-discussed NP characteristics in brain delivery.
  • To provide examples of how NP functionalization impacts the success of nano-based delivery systems.

Main Methods:

  • Review of existing literature on nanoparticle (NP) design for brain delivery.
  • Discussion of commonly addressed NP properties (size, charge, shape, ligand functionalization).
  • Emphasis on under-discussed NP properties (ligand density, linker length, avidity, protein corona, stiffness).

Main Results:

  • Careful design of NP properties, including size, charge, shape, and ligand functionalization, is essential for successful brain delivery.
  • Properties such as ligand density, linker length, avidity, protein corona, and stiffness are critical but often overlooked factors.
  • Targeting ligands and specific functionalization parameters significantly affect NP transport across the BBB.

Conclusions:

  • Optimizing nanoparticle (NP) properties is vital for overcoming the blood-brain barrier (BBB) and achieving effective CNS drug delivery.
  • Under-explored NP characteristics offer significant potential for improving therapeutic outcomes in neurological disorders.
  • Strategic NP functionalization can enhance targeting and accumulation in the brain, paving the way for advanced nanomedicine.