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Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
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Biofunctionalized Nano-antimicrobials - Progress, Prospects and Challenges.

Lutfur Rahman1,2, Sabahat Asif3, Ata Ullah1,2

  • 1National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, 38000, Pakistan.

Current Topics in Medicinal Chemistry
|December 28, 2021
PubMed
Summary
This summary is machine-generated.

New natural product-based nano-antibiotics using functionalized nanoparticles show promise against multidrug-resistant (MDR) bacteria. This review highlights their potential to overcome antibiotic resistance and reduce side effects.

Keywords:
Cationic polymersFlavonoidsMultidrug resistanceNano-antimicrobialsPathogenic bacterial strainsShort peptides

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Area of Science:

  • Nanomedicine
  • Microbiology
  • Materials Science

Background:

  • Rising multidrug-resistant (MDR) bacterial strains pose significant healthcare challenges.
  • Conventional antibiotics exhibit adverse side effects, necessitating safer alternatives.
  • Natural products offer a promising source for developing novel antimicrobial agents.

Purpose of the Study:

  • To review recent advancements in natural product-based nano-antibiotics.
  • To focus on flavonoids, peptides, and cationic biopolymers functionalized nanoparticles.
  • To evaluate their efficacy against MDR bacterial strains.

Main Methods:

  • Review of scientific literature on functionalized nanoparticles.
  • Analysis of minimal inhibitory concentrations (MICs) against pathogenic bacteria.
  • Investigation of cellular and molecular mechanisms of action.

Main Results:

  • Functionalized nanoparticles demonstrate significant antimicrobial activity against MDR strains.
  • Flavonoid, peptide, and biopolymer-based nanoparticles show potent efficacy.
  • Mechanisms of action at cellular and molecular levels are elucidated.

Conclusions:

  • Natural product-based nano-antibiotics are effective against MDR bacteria.
  • These nano-formulations offer a promising alternative to conventional antibiotics.
  • Further research is needed to enable in vivo applications of nano-antimicrobials.