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The Retinoblastoma Gene01:20

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Updated: Oct 8, 2025

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
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Retinal granular cell tumor: a case report.

Jimin Park1, Kyung-Ja Cho2, Junyeop Lee3

  • 1Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

BMC Ophthalmology
|December 28, 2021
PubMed
Summary
This summary is machine-generated.

A rare case of a granular cell tumor invading the retina caused severe vision loss. This benign neoplasm, when affecting the optic nerve head, can lead to devastating visual impairment.

Keywords:
Case reportGranular cell tumorIntraocular tumor

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Reports a rare instance of granular cell tumor impacting the retina.
  • Highlights the diagnostic and therapeutic challenges of intraocular tumors.

Observation:

  • A 56-year-old female presented with blurred vision and was found to have an inferonasal retinal mass near the optic disc.
  • The mass was associated with dense exudation and extensive serous retinal detachment.
  • Intravitreal bevacizumab injections did not control exudation or intraocular pressure (IOP).

Findings:

  • Vitrectomy facilitated retinal re-attachment and tumor biopsy.
  • Histopathology confirmed the intraocular mass as a granular cell tumor.
  • Immunohistochemistry showed positivity for S100, CD68, and focal neurofilaments; negative for ERG and HMB-45.

Implications:

  • Granular cell tumors, though typically benign, pose a significant risk of profound vision loss when involving the retina near the optic nerve head.
  • Despite surgical intervention, the patient experienced worsening vision and elevated IOP due to uncontrolled exudation.