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Can serum periostin predict bronchopulmonary dysplasia in premature infants?
Hayato Go1, Junya Ono2, Hitoshi Ohto3
1Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan. gohayato2525@gmail.com.
Insights
Higher serum periostin levels at birth may indicate bronchopulmonary dysplasia (BPD) risk in preterm infants. This finding could aid in early BPD detection and management.
Area of Science:
- Neonatology
- Pediatric Pulmonology
- Biomarker Discovery
Background:
- Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth, impacting long-term respiratory health.
- Identifying reliable biomarkers for BPD is crucial for timely intervention and improved outcomes.
Purpose of the Study:
- To investigate serum periostin as a potential biomarker for BPD in preterm infants.
- To assess periostin levels at birth, day of life 28, and corrected gestational age.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure serum periostin levels.
- Study included 98 preterm infants (<32 weeks gestation) and 41 healthy term controls.
- Infants were categorized into BPD (n=44) and non-BPD (n=54) groups.
Main Results:
- Median serum periostin levels at birth were significantly higher in preterm infants who developed BPD (338.0 ng/mL) compared to those who did not (275.0 ng/mL).
- Serum periostin levels at birth were significantly associated with BPD development (P=0.013).
- Higher levels were observed in moderate/severe BPD cases compared to non-BPD/mild BPD cases.
Conclusions:
- Elevated serum periostin at birth is a potential indicator for BPD in preterm infants.
- Serum periostin levels at birth correlate with gestational age and birth weight.
- Further research is needed to elucidate the mechanisms of periostin upregulation in BPD.
Background:
Bronchopulmonary dysplasia (BPD) is the most common morbidity complicating preterm birth and affects long-term respiratory outcomes. The objectives of this study were to establish whether serum periostin at birth, day of life (DOL) 28, and corrected 36 weeks' gestational age could be potential biomarkers for BPD.
Methods:
A total of 98 preterm Japanese infants born at <32 weeks and comparing 41 healthy controls born at term, were divided into BPD (n = 44) and non-BPD (n = 54) cohorts. Serum periostin levels were measured using an enzyme-linked immunosorbent assay.
Results:
Among 98 preterm infants, the median serum periostin levels at birth were higher with BPD (338.0 ng/mL) than without (275.0 ng/mL, P < 0.001). Multivariate analysis revealed that serum periostin levels at birth were significantly associated with BPD (P = 0.013). Serum periostin levels at birth with moderate/severe BPD (345.0 ng/mL) were significantly higher than those with non-BPD/mild BPD (283.0 ng/mL, P = 0.006).
Conclusions:
Serum periostin levels were significantly correlated with birth weight and gestational age, and serum periostin levels at birth in BPD infants were significantly higher than that in non-BPD infants.
Impact:
This study found higher serum periostin levels at birth in preterm infants subsequently diagnosed with bronchopulmonary dysplasia. It also emerged that serum periostin levels at birth significantly correlated with gestational age and birth weight. The mechanism by which serum periostin is upregulated in BPD infants needs further investigation.
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