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Antibacterial sesquiterpenoids from Solanum lyratum
Jun Liang1, Wenbin Liang1, Xintao Chen1,2
1Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.
Abstract:
Investigation into the chemical diversity of Solanum lyratum led to the discovery of one new sesquiterpenoid, solyraterpenoid A (1), and two known compounds (2 and 3). The structure incorporating absolute configuration of 1 was determined via spectroscopic data, mainly including HRESIMS and NMR, and single-crystal X-ray diffraction analysis. Compound 1 showed significant antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae with MIC values of 8, 8, and 4 μg/mL, respectively.
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