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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

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Controlling Water Flow through a Synthetic Nanopore with Permeable Cations.

Yi Shen¹, Fan Fei¹, Yulong Zhong²

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

ACS Central Science

|December 29, 2021

Summary

This summary is machine-generated.

Researchers developed a novel synthetic nanopore with tunable water transport, mimicking biological channels. This self-assembling system

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High Resolution Physical Characterization of Single Metallic Nanoparticles

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Published on: June 28, 2019

Area of Science:

Nanotechnology
Biomimetic Engineering
Materials Science

Background:

Intense interest exists in synthetic nanopores mimicking biological water channels.
Existing synthetic channels lack regulated water transport, a key feature of natural channels.
Current synthetic water channels possess hydrophobic lumens.

Purpose of the Study:

To design and characterize a self-assembling synthetic nanopore with regulated water transport.
To investigate the mechanism of ion-mediated water flow modulation.
To provide a proof-of-concept for controllable synthetic water channels.

Main Methods:

Self-assembly of macrocyclic molecules into a hybrid hydrophilic/hydrophobic nanopore.
Stopped-flow kinetic assays to measure water transport rates.
All-atom molecular dynamics simulations to elucidate the transport mechanism.

Main Results:

The synthetic nanopore exhibits ion-regulated water transport.
Water flow is dependent on alkali metal cation size, showing a non-monotonic relationship.
Water transport ranges from negligible (with sodium ions) to rates comparable to aquaporin 1 (without cations).

Conclusions:

Cation binding within the hybrid pore modulates water flow.
This work offers insights into high-flux water transport through sub-nanometer pores.
A new paradigm for designing controllable synthetic water channels is established.