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Respiratory Tract Microecology and Bronchopulmonary Dysplasia in Preterm Infants

Tong Sun1, Haiyang Yu2, Jianhua Fu1

  • 1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Frontiers in Pediatrics
|December 30, 2021
PubMed

Insights

Bronchopulmonary dysplasia (BPD) in preterm infants is linked to respiratory tract microecology changes. Understanding these microbial shifts offers new prevention and treatment strategies for BPD.

Area of Science:

  • Neonatal Medicine
  • Microbiology
  • Pulmonology

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant respiratory issue in premature infants.
  • The complex causes of BPD are not fully understood, but respiratory tract microecology is implicated.
  • Abnormal microbial diversity and altered microbial patterns precede BPD development.

Purpose of the Study:

  • To review microecological changes in the neonatal respiratory tract.
  • To explore the mechanisms linking these changes to BPD.
  • To identify potential new avenues for BPD prevention and treatment.

Main Methods:

  • Literature review of studies on neonatal respiratory tract microecology and BPD.
  • Analysis of research on microbial colonization and evolution in preterm infants.
  • Synthesis of current understanding of BPD pathogenesis related to microecology.

Main Results:

  • Evidence suggests a correlation between respiratory tract microecology and BPD.
  • Specific alterations in microbial diversity and dynamics are observed in infants who develop BPD.
  • The review consolidates findings on the role of the microbiome in BPD.

Conclusions:

  • Microecological changes in the neonatal respiratory tract play a role in BPD development.
  • Further research into the neonatal microbiome is crucial for developing targeted BPD interventions.
  • Understanding these mechanisms could lead to novel therapeutic strategies.

Keywords:
bronchopulmonary dysplasiagut-lung axislung developmentmicrobiotamicroecologypreterm infants

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