[Urethral microbiome in patients with pulmonary tuberculosis].
A G Cherednichenko1, E V Kulchavenya1,2, Evdokimova S L1
1TB Research Institute of Ministry of Health of Russia, Novosibirsk, Russia.
Urologiia (Moscow, Russia : 1999)
|December 30, 2021
Summary
Long-term tuberculosis treatment significantly alters the male urethral microbiome. Antibiotic therapy impacts bacterial composition, differing from healthy controls.
Area of Science:
- Microbiology
- Urology
- Infectious Diseases
Background:
- Tuberculosis treatment necessitates prolonged antimicrobial drug use.
- Broad-spectrum antibiotics can disrupt the urinary tract's microflora.
Purpose of the Study:
- To investigate the impact of long-term antibiotic therapy on the male urethral microbiome.
- To compare urethral microflora in tuberculosis patients undergoing treatment versus controls.
Main Methods:
- Prospective study of 75 men: 63 with tuberculosis, 12 controls.
- Urethral swabs analyzed using real-time polymerase chain reaction (RT-PCR).
- Quantitative assessment of microbial composition (GE/ml).
Main Results:
- Tuberculosis patients showed distinct urethral microflora compared to controls.
- Increased prevalence of Corynebacterium spp. in tuberculosis patients (49.2%).
- Enterobacteriaceae/Enterococcus and Staphylococcus spp. detected in significant proportions in both groups.
Conclusions:
- Long-term tuberculosis chemotherapy significantly alters the male urethral microbiome.
- Differences in urethral microflora spectrum observed between tuberculosis patients and controls without urinary tract infections.
Keywords:
PCRandroflorchemotherapymicrobiomemicrobiotamicrofloratuberculosisurethraurogenital infectionsMore Related Videos
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