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Applying Pharmacogenomic Guidelines to Combat Medical Care.
Jesse DeLuca1, Thomas Oliver2, Chad Hulsopple3
1Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Military Medicine
|December 30, 2021
Summary
Pharmacogenomics can optimize treatment for military personnel in deployed settings. This review identifies key drugs and genetic factors for improved battlefield medical care, especially in prolonged field situations.
Area of Science:
- Pharmacogenomics
- Military Medicine
- Personalized Medicine
Background:
- Pharmacogenomics is crucial for personalized medicine, offering optimized treatments.
- Military medicine in deployed settings presents unique challenges and requires specific assessment.
- The application of pharmacogenomics for US Active Duty Service Members in deployed settings has not been previously reviewed.
Purpose of the Study:
- To assess the potential capabilities and impact of pharmacogenomics in deployed military medical care.
- To identify pharmacogenomic applications within the context of forward medical care, referencing TCCC and EWS guidelines.
- To review existing literature and provide a foundation for future research in this area.
Main Methods:
- Identified all drugs within the TCCC guidelines and EWS book.
- Cross-referenced identified drugs with Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines and FDA pharmacogenomic biomarker information.
- Tabulated drugs and their associated pharmacogenomic liabilities.
Main Results:
- Ten pharmacologic categories and 15 drugs were identified, including aminoglycosides, beta-blockers, and volatile anesthetics.
- Eight specific drugs or classes were highlighted for their potential impact on battlefield treatment during prolonged field care.
- Several genes with liabilities relevant to prolonged field care were identified.
Conclusions:
- Pharmacogenomics holds significant potential for enhancing medical care on the battlefield.
- Further study is needed to fully leverage pharmacogenomic insights for improved treatment of service members in deployed and prolonged field care settings.
- This review provides a foundational understanding of pharmacogenomic applications in military medicine.
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