Related Experiment Video
Updated: Oct 8, 2025
07:51
Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
5.1K
SAPHO syndrome and pustulotic arthro-osteitis
Mitsumasa Kishimoto1, Yoshinori Taniguchi2, Shigeyoshi Tsuji3
1Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan.
Modern Rheumatology
|December 30, 2021
Summary
Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis (SAPHO) syndrome is a rare inflammatory condition. This review covers its musculoskeletal features, diagnosis, and management strategies for improving patient quality of life.
Area of Science:
- Rheumatology
- Dermatology
- Osteoarticular Disorders
Background:
- Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis (SAPHO) syndrome is a rare inflammatory osteoarticular disorder.
- It encompasses conditions like pustulotic arthro-osteitis (PAO), characterized by osteitis, synovitis, and hyperostosis.
- SAPHO syndrome and PAO predominantly affect individuals aged 30-50, with a female predominance.
Purpose of the Study:
- To review the clinical, radiological, and laboratory features of SAPHO syndrome.
- To outline diagnostic criteria for SAPHO syndrome and PAO.
- To discuss non-pharmacological and pharmacological management strategies.
Main Methods:
- Literature review of SAPHO syndrome and related conditions.
- Analysis of epidemiological data, including prevalence and demographics.
- Summary of diagnostic approaches and treatment goals.
Main Results:
- PAO is a significant component of SAPHO syndrome, particularly in Japan.
- Severe acne is a common skin manifestation in SAPHO patients, especially in Israel.
- Prevalence data for SAPHO syndrome is limited, but palmoplantar pustulosis (PPP) affects 0.12% in Japan, with 10-30% of PPP patients having PAO.
Conclusions:
- Effective diagnosis relies on identifying diverse clinical, radiological, and laboratory features.
- Treatment aims to enhance quality of life, prevent structural damage, and restore physical and social function.
- Comprehensive management involves both non-pharmacological and pharmacological interventions.
Related Concept Videos
01:23Rheumatic Heart Disease I: Introduction
78
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
78
01:23Skin Diseases and Disorders
4.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.4K
01:24Nephrotic Syndrome I : Introduction
72
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
72
01:30Bacterial Phylum Spirochaetes
159
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
159
01:25Endocarditis II: Clinical Features of Infective Endocarditis
43
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
43