Pd-Immobilized Schiff Base Double-Layer Macrocycle: Synthesis, Structures, Peroxidase Mimic Activity, and...

Area of Science:

• Supramolecular Chemistry
• Materials Science
• Nanotechnology

Background:

• Schiff base macrocycles are versatile platforms for creating functional materials.
• Palladium (Pd) composites offer potential in catalysis and biomedical applications.
• Enzyme mimetics and antibacterial agents are crucial in various scientific fields.

Purpose of the Study:

• To synthesize novel double-layer Schiff base macrocycles using di-, tri-, and tetra-aldehydes.
• To immobilize palladium (Pd) onto a [2 + 3] Schiff base macrocycle for catalytic applications.
• To evaluate the peroxidase-like activity and antibacterial efficacy of the Pd@Schiff base composite.

Main Methods:

• Synthesis of Schiff base macrocycles via condensation reactions.
• Immobilization of palladium onto the synthesized macrocycle.
• Assay of peroxidase-like activity using 3,3',5,5'-tetramethylbenzidine (TMB) substrate.
• Evaluation of bactericidal activity against Escherichia coli and Staphylococcus aureus.
• Cytotoxicity assessment of the Pd composite.

Main Results:

• Successful synthesis of [2 + 2], [2 + 3], and [2 + 4] double-layer Schiff base macrocycles.
• The Pd@Schiff base composite demonstrated significant peroxidase-like catalytic activity.
• The composite exhibited potent bactericidal effects against both Gram-negative and Gram-positive bacteria.
• Cytotoxicity studies confirmed the biosafety of the palladium composite.

Conclusions:

• The developed Pd@Schiff base composite functions effectively as an enzyme mimetic.
• This composite shows promising potential as a broad-spectrum antibacterial agent.
• The findings support the development of novel Pd-based composites for enzyme mimicry and antimicrobial applications.