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Bilateral testicular Leydig cell hyperplasia presented incidentally: A case report
Mohammad Al-Zubi1, Mohammad Araydah2, Sarah Al Sharie2
1Department of Clinical Sciences, Urology Division, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
International Journal of Surgery Case Reports
|December 30, 2021
Summary
Leydig cell hyperplasia is a rare testicular condition causing increased Leydig cells. Differentiating it from Leydig cell tumors is crucial to prevent unnecessary interventions.
Area of Science:
- Andrology
- Endocrinology
- Uropathology
Background:
- Leydig cell hyperplasia (LCH) is an uncommon condition, accounting for less than 3% of testicular tumors.
- It involves an increase in the size and number of Leydig cells, which produce testosterone.
Purpose of the Study:
- To present a case of Leydig cell hyperplasia in an adult male.
- To highlight the diagnostic challenges and importance of differentiating LCH from Leydig cell tumors.
Main Methods:
- A 48-year-old male presented with erectile dysfunction and decreased libido.
- Scrotal ultrasound revealed bilateral hypoechoic testicular masses.
- Left orchidectomy was performed, and histopathology confirmed the diagnosis.
Main Results:
- Histopathology confirmed Leydig cell hyperplasia.
- The patient presented with symptoms suggestive of hormonal imbalance.
Conclusions:
- Leydig cell hyperplasia is a rare, predominantly benign condition affecting adults and children.
- Adult LCH can be associated with conditions like Klinefelter's syndrome or hCG therapy, but often occurs idiomatically.
- Scrotal ultrasound and tumor markers aid in diagnosis; differentiation from Leydig cell tumors is essential to guide appropriate management and avoid overtreatment.
