Nuclear Factor IA Is Down-regulated in Muscle-invasive and High-grade Bladder Cancers
Maciej Kaczorowski1, Joanna Matysiak2, Pawel Kielb3
1Department of Clinical and Experimental Pathology, Wroclaw Medical University, Wroclaw, Poland maciej.kaczorowski@umed.wroc.pl.
Background/Aim:
Nuclear factor I (NFI) A and NFIB are transcription factors involved in the regulation of cell differentiation and organ development. More recently, they have been implicated in the pathogenesis of cancer, acting as context-dependent tumor promoters or suppressors.
Materials And Methods:
Expression of NFIA and NFIB was assessed by immunohistochemistry in 136 primary urothelial bladder cancers.
Results:
Progressive down-regulation of NFIA was observed with increasing pT stages and higher grade of analyzed tumors. Consequently, muscle invasive cancers exhibited lower NFIA expression compared with non-muscle invasive cases. Analogous comparisons yielded negative results in the case of NFIB. Expression of neither protein was associated with patient survival.
Conclusion:
NFIA may act as a suppressor of urothelial carcinogenesis, but functional studies and understanding of post-transcriptional regulation of NFI expression is necessary to dissect its role in bladder malignancies.
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