Related Experiment Video
Updated: Oct 8, 2025
06:02
Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
36.9K
Multiple painful plaques and the Sweet's syndrome
Debra Lee1, Daniel Baird2, Michelle Tarbox2
1Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas.
Proceedings (Baylor University. Medical Center)
|December 31, 2021
Summary
A rare case of Sweet's syndrome (acute febrile neutrophilic dermatosis) was diagnosed in a 39-year-old woman presenting with fever and painful skin plaques. Prompt diagnosis via skin biopsy is vital for identifying associated systemic disorders.
Area of Science:
- Dermatology
- Internal Medicine
- Pathology
Background:
- Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory condition.
- It is characterized by the sudden onset of fever, neutrophilia, and characteristic skin lesions.
Observation:
- A 39-year-old woman presented with subjective fevers, polyarthralgia, and malaise.
- She developed worsening, painful erythematous plaques on her trunk, arms, and legs.
Findings:
- Skin biopsy confirmed the diagnosis of acute febrile neutrophilic dermatosis (Sweet's syndrome).
- This diagnosis necessitates evaluation for underlying systemic conditions like leukemia, inflammatory bowel disease, and infections.
Implications:
- Early diagnosis through skin biopsy is critical for timely management.
- Sweet's syndrome management often involves systemic corticosteroids or potassium iodide.
- Identifying and treating associated disorders is crucial for patient outcomes.
Related Concept Videos
03:03Amyloid Fibrils
10.6K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
10.6K
01:25Endocarditis II: Clinical Features of Infective Endocarditis
43
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
43
01:30Atherosclerosis I: Introduction
157
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
157
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
76
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
76
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
57
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
57
01:24Nephrotic Syndrome I : Introduction
72
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
72