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Updated: Oct 8, 2025
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
19.1K
Myocardial infarction and factor VIII elevation in a 36-year-old man
Amit Alam1, Harsh Doshi2, Divya N Patel3
1Division of Advanced Heart Failure, Baylor University Medical Center, Dallas, Texas.
Proceedings (Baylor University. Medical Center)
|December 31, 2021
Summary
High factor VIII activity can cause arterial and venous thrombosis, even in young patients without traditional risk factors. This case highlights the importance of thrombophilia testing in unexplained clotting events.
Area of Science:
- Cardiology
- Hematology
- Genetics
Background:
- Factor VIII is implicated in arterial thrombosis, including myocardial infarction and stroke.
- Atherosclerosis and traditional cardiac risk factors are common causes of myocardial infarction.
Observation:
- A 36-year-old man experienced myocardial infarction without typical cardiac risk factors.
- The patient developed end-stage heart failure, requiring a left ventricular assist device (LVAD), which thrombosed twice.
- Following a heart-kidney transplant, the patient suffered deep vein thrombosis in his lower extremity.
Findings:
- Thrombophilia workup revealed significantly elevated factor VIII activity (319%).
- The patient was initiated on apixaban for indefinite anticoagulation.
- No further thrombotic events occurred during 18 months of follow-up.
Implications:
- Elevated factor VIII activity is a potential cause of recurrent arterial and venous thrombosis.
- Comprehensive thrombophilia screening is crucial for patients with unexplained thromboembolic events.
- Anticoagulation therapy can effectively manage thrombosis in individuals with high factor VIII activity.
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